cell cycle gene การใช้

• Nurse isolated the human version of a key cell cycle gene, called CDK1, in 1987.
• HDACs 1 and 2 have been found to express regulatory roles in key cell cycle genes including p21.
• EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.
• The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
• Current studies are aimed at investigating how cytoskeletal matrix interactions lead to the profound cellular changes that we have observed through a detailed analysis of cell cycle gene alterations, metalloproteinase and inhibitor secretion and ultrastructural cytoskeletal relationships.
• Indeed, tracking the expression of FUS1pr-GFP, a mating pathway gene, and of CLN2pr-mCherry, a cell cycle gene, showed great coexpression in STE5-8A cells relative to wild type cells.
• Tumour growth can occur by a combination of factors, including a mutation in a cell cycle gene which removes the restrains of cell growth, combined with mutations in apoptopic proteins such as Caspases that would respond by inducing cell death in abnormal growing cells.